Long-Term Follow-Up of Autonomic and Enteric Measures in Patients Undergoing Vertical Banded Gastroplasty for Morbid Obesity

Neil E. Crittenden, Hani Rashed, William D. Johnson, George Cowan, David Tichansky, Atul Madan, Naeem Aslam, Teresa Cutts, Thomas L. Abell

Abstract


Background: A multi-component model of autonomic and enteric factors may correlate with ultimate weight loss or gain after restrictive obesity surgery. This study aimed to determine relevant parameters to predict successful long-term weight loss.

Methods: Thirty-nine patients (four males and 35 females) with a mean age of 37.2 years were followed for over 15 years after vertical banded gastroplasty. Baseline adrenergic: postural adjustment ratio (PAR) and vasoconstriction (VC); cholinergic: electrocardiogram R-to-R interval (RRI) and enteric measure: electrogastrogram (EGG) were utilized by a discriminant function analysis to classify patients as a long-term loser or gainer. Using latest weight compared to baseline, patients were divided as 10 gainers and 29 losers.

Results: A discriminate model successfully predicted ultimate weight gain in 8/10 (80%) of patients who subsequently gained weight and weight loss in 24/29 (83%) of patients who lost weight for a total correct classification of 32/39 (82%). The same model with data at 3 months postoperatively predicted weight gain in 9/10 (90%) of patients and weight loss in 24/29 (83%) of patients, for a total correct classification of 34/39 (87%).

Conclusions: A multi-component model at baseline and 3 months postoperative can predict long-term weight outcome from restrictive obesity surgery.




Gastroenterol Res. 2017;10(4):218-223
doi: https://doi.org/10.14740/gr885w

 


Keywords


Obesity; Vertical banded gastroplasty; Autonomic nervous system; Eenteric nervous system

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