Email this article 
Increased Expression of Matrix Metalloproteinase-1 and 3 in Remission Patients of Steroid-Dependent Ulcerative Colitis
Abstract
Background: This study was to investigate the pathological significance of protein expression of matrix metalloproteinase-1 (MMP1) and matrix metalloproteinase-3 (MMP3) in colon tissues of remission patients of steroid-dependent uncreative colitis (SDUC).
Methods: To test the possible involvement of MMP-1 and MMP-3 in SDUC, Western- blot and immunohistochemistry were applied to examine the protein expression of MMP-1 and MMP-3 in the colonic healing region from 10 remission patients with SDUC as well as from 10 remission patients with non-SDUC. Ten specimens from normal colon tissues were used as controls.
Results: Compared with the control group, the protein expression of MMP-1 and MMP-3 from non-SDUC remission patients slightly increased (p > 0.05), in contrast, those from SDUC patients significantly increased (p < 0.01).
Conclusions: Over-expression of MMP-1 and MMP-3 play a critical role in the pathogenesis of SDUC.
Gastroenterol Res. 2010;3(3):120-124
doi: https://doi.org/10.4021/gr2010.05.208w
Methods: To test the possible involvement of MMP-1 and MMP-3 in SDUC, Western- blot and immunohistochemistry were applied to examine the protein expression of MMP-1 and MMP-3 in the colonic healing region from 10 remission patients with SDUC as well as from 10 remission patients with non-SDUC. Ten specimens from normal colon tissues were used as controls.
Results: Compared with the control group, the protein expression of MMP-1 and MMP-3 from non-SDUC remission patients slightly increased (p > 0.05), in contrast, those from SDUC patients significantly increased (p < 0.01).
Conclusions: Over-expression of MMP-1 and MMP-3 play a critical role in the pathogenesis of SDUC.
Gastroenterol Res. 2010;3(3):120-124
doi: https://doi.org/10.4021/gr2010.05.208w
Keywords
Ulcerative colitis; Metalloproteinase; Steroid-dependent