Increased Expression of Matrix Metalloproteinase-1 and 3 in Remission Patients of Steroid-Dependent Ulcerative Colitis

Zhi Yong Wang, Bing Feng Qiu

Abstract


Aims: This study was to investigate the pathological significance of protein expression of matrix metalloproteinase-1 (MMP1) and matrix metalloproteinase-3 (MMP3) in colon tissues of remission patients of steroid-dependent uncreative colitis (SDUC).

Methods: To test the possible involvement of MMP-1 anMMP-3 in SDUC, Western- blot and immunohistochemistry were applied to examine the protein expression of MMP-1 and MMP-3 in the colonic healing region from 10 remission patients with SDUC as well as from 10 remission patients with non-SDUC. Ten specimens from normal colon tissues were used as controls.

Results: Compared with the control group, the protein expression of MMP-1 and MMP-3 from non-SDUC remission patients slightly increased (p > 0.05), in contrast, those from SDUC patients significantly increased (p < 0.01).

Conclusions: Over-expression of MMP-1 and MMP-3 play a critical role in the pathogenesis of SDUC.




doi:10.4021/gr2010.05.208w


Keywords


Ulcerative colitis; Metalloproteinase; Steroid-dependent

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