High Seroprevalence of Helicobacter Pylori Infection in Inmates: A Case Control Study in a Northern Mexican City

Cosme Alvarado-Esquivel, Jesus Hernandez-Tinoco, Luis Francisco Sanchez-Anguiano, Agar Ramos-Nevarez, Sandra Margarita Cerrillo-Soto, Leandro Saenz-Soto

Abstract


Background: The epidemiology of Helicobacter pylori infection in inmates has not been previously studied. Therefore, we determine the seroepidemiology of H. pylori infection in inmates.

Methods: Through a case-control study, inmates from a state correctional facility in Durango, Mexico and subjects without incarceration of the same city were examined for the presence of anti-H. pylori IgG antibodies using enzyme-linked immunoassays. Seroprevalence association with socio-demographic, incarceration, clinical and behavioral characteristics of the inmates was also investigated.

Results: Antibodies to H. pylori were found in 140 (83.3%) of 168 inmates and in 101 (60.1%) of 168 controls. Seroprevalence of anti-H. pylori IgG antibodies was significantly higher in inmates than in controls (OR = 3.32; 95% CI: 1.93 - 5.71; P = 0.000002). The seroprevalence of H. pylori infection was not influenced by gender, age, or socioeconomic status of inmates. Seropositivity to H. pylori was found in 3 of 3 inmates with peptic ulcer and in 1 of 2 inmates with gastritis. The seroprevalence of H. pylori exposure was high regardless the jail section, duration (years) in incarceration and number of incarcerations. Multivariate analysis revealed that H. pylori exposure was positively associated with having tattoos (OR = 3.34; 95% CI: 1.14 - 9.70; P = 0.02), and negatively associated with drug abuse (OR = 0.28; 95% CI: 0.11 - 0.70; P = 0.007).

Conclusions: Seroprevalence of H. pylori exposure in inmates is higher than those found in non-incarcerated people and other populations in the region. Results indicate that inmates may represent a new risk group for H. pylori exposure. Results warrant for further research on the potential role of incarceration and behavioral features of inmates for H. pylori infection.




Gastroenterology Research. 2013;6(6):227-232
doi: http://dx.doi.org/10.4021/gr583w


Keywords


Helicobacter pylori; Seroprevalence; Inmates; Epidemiology; Mexico

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