Budd-Chiari Syndrome as an Initial Presentation of Non-Promyelocytic Acute Myelogenous Leukemia

Jiten P. Kothadia, Vanisha Patel, Rajiv Heda, Wesley A. Angel, Vishwas Vanar, Benedict J. Maliakkal, Rajanshu Verma


Budd-Chiari syndrome (BCS) is a rare disease characterized by hepatic venous outflow tract obstruction, frequently due to an underlying thrombophilic disorder. Acute myeloid leukemia rarely presents as acute BCS due to hyperfibrinolysis, hyperleukocytosis, nonspecific proteolytic activity, and disseminated intravascular coagulation causing acute hepatic vein thrombosis. In patients presenting with acute BCS with acute liver failure (ALF), a high index of suspicion and exclusion of underlying malignancy is a must, as it is a contraindication for liver transplantation. We report a case of a 19-year-old Caucasian male who presented with acute BCS causing ALF as an initial presentation of acute myelogenous leukemia.

Gastroenterol Res. 2022;15(3):148-154
doi: https://doi.org/10.14740/gr1530


Budd-Chiari syndrome; Acute promyelocytic leukemia; Acute myeloid leukemia; Thrombophilia; Leukemia; Acute liver failure


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