Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website http://www.gastrores.org

Original Article

Volume 7, Number 5-6, December 2014, pages 111-117

Body Mass Index Is Associated With Mucosal Disease in Crohn’s: Results of a Case-Control Study

**Table 1.** Characteristics of Cases and Controls
Characteristic	Cases (N = 36)	Controls (N = 68)
BMI, median (range)	27 (19 - 44)	24 (19 - 46)
Obese	12 (33%)	12 (18%)
Age, median (range)	37 (20 - 79)	35 (19 - 72)
Duration of disease, median (range)	5 (1 - 37)	7 (1 - 36)
Duration of observation, median (range)	1 (1 - 4)	2 (1 - 4)
Caucasian/African American	18/18 (50%/50%)	26/42 (38%/62%)
Men/women	15/21 (42%/58%)	25/43 (37%/63%)
Age at diagnosis, median (range)	27 (10 - 75)	25 (11 - 68)
Perianal disease	12 (33%)	24 (35%)
Tobacco consumption	9 (25%)	13 (19%)
Steroid use	16 (44%)	20 (29%)
FH AID	6 (17%)	12 (18%)
FH cancer	10 (29%)	13 (20%)
FH CRC	3 (5%) (N = 35)	4 (11%) (N = 66)
FH IBD	5 (14%)	7 (10%)
AZA/6-MP use	19 (53%)	35 (51%)
Biologic use	25 (69%)	50 (73%)
Methotrexate use	6 (17%)	8 (12%)
Diabetes mellitus	4 (11%)	5 (7%)
EIM	18 (50%)	23 (34%)

Table 1. Characteristics of Cases and Controls

Characteristic

Cases (N = 36)

Controls (N = 68)

BMI, median (range)

27 (19 - 44)

24 (19 - 46)

Obese

12 (33%)

12 (18%)

Age, median (range)

37 (20 - 79)

35 (19 - 72)

Duration of disease, median (range)

5 (1 - 37)

7 (1 - 36)

Duration of observation, median (range)

1 (1 - 4)

2 (1 - 4)

Caucasian/African American

18/18 (50%/50%)

26/42 (38%/62%)

Men/women

15/21 (42%/58%)

25/43 (37%/63%)

Age at diagnosis, median (range)

27 (10 - 75)

25 (11 - 68)

Perianal disease

12 (33%)

24 (35%)

Tobacco consumption

9 (25%)

13 (19%)

Steroid use

16 (44%)

20 (29%)

FH AID

6 (17%)

12 (18%)

FH cancer

10 (29%)

13 (20%)

FH CRC

3 (5%) (N = 35)

4 (11%) (N = 66)

FH IBD

5 (14%)

7 (10%)

AZA/6-MP use

19 (53%)

35 (51%)

Biologic use

25 (69%)

50 (73%)

Methotrexate use

6 (17%)

8 (12%)

Diabetes mellitus

4 (11%)

5 (7%)

EIM

18 (50%)

23 (34%)

**Table 2.** Difference in Relevant Covariates Between Cases and Controls
Covariate	Cases (N = 36)	Controls (N = 68)	P value
BMI, median (range)	27 (19 - 44)	24 (19 - 46)	0.024
Obese	12 (33%)	12 (18%)	0.0709
Age, median (range)	37 (20 - 79)	35 (19 - 72)	0.413
Duration of disease, median (range)	5 (1 - 37)	7 (1 - 36)	0.1742
Duration of observation, median (range)	1 (1 - 4)	2 (1 - 4)	0.69
Caucasian/African American	18/18 (50%/50%)	26/42 (38%/62%)	0.249
Men/women	15/21 (42%/58%)	25/43 (37%/63%)	0.625

Table 2. Difference in Relevant Covariates Between Cases and Controls

Covariate

Cases (N = 36)

Controls (N = 68)

P value

BMI, median (range)

27 (19 - 44)

24 (19 - 46)

0.024

Obese

12 (33%)

12 (18%)

0.0709

Age, median (range)

37 (20 - 79)

35 (19 - 72)

0.413

Duration of disease, median (range)

5 (1 - 37)

7 (1 - 36)

0.1742

Duration of observation, median (range)

1 (1 - 4)

2 (1 - 4)

0.69

Caucasian/African American

18/18 (50%/50%)

26/42 (38%/62%)

0.249

Men/women

15/21 (42%/58%)

25/43 (37%/63%)

0.625

**Table 3.** Multivariable Full Model for BMI as a Categorical Variable*
Effect	Point estimate	95% CI	P value
*Adjusted for age, sex, race, duration of disease and observation.
Obese vs. non-obese	2.716	1.004 - 7.349	0.0492
Age now	0.994	0.962 - 1.027	0.7065
Sex	1.567	0.627 - 3.913	0.3361
Race	1.748	0.725 - 4.215	0.2135
Duration of observation	0.824	0.505 - 1.325	0.4395
Duration of disease	0.995	0.941 - 1.052	0.8604

Table 3. Multivariable Full Model for BMI as a Categorical Variable*

Effect

Point estimate

95% CI

P value

*Adjusted for age, sex, race, duration of disease and observation.

Obese vs. non-obese

2.716

1.004 - 7.349

0.0492

Age now

0.994

0.962 - 1.027

0.7065

Sex

1.567

0.627 - 3.913

0.3361

Race

1.748

0.725 - 4.215

0.2135

Duration of observation

0.824

0.505 - 1.325

0.4395

Duration of disease

0.995

0.941 - 1.052

0.8604

**Table 4.** Multivariable Full Model for BMI as a Continuous Variable*
Effect	Point estimate	95% CI	P value
*Adjusted for age, sex, race, duration of disease and observation.
BMI	1.09	1.019 - 1.166	0.0122
Age	0.992	0.959 - 1.025	0.6206
Sex	1.371	0.556 - 3.381	0.4933
Race	1.567	0.646 - 3.798	0.3206
Duration of observation	0.787	0.477 - 1.298	0.3486
Duration of disease	1.001	0.945 - 1.059	0.9828

Table 4. Multivariable Full Model for BMI as a Continuous Variable*

Effect

Point estimate

95% CI

P value

*Adjusted for age, sex, race, duration of disease and observation.

BMI

1.09

1.019 - 1.166

0.0122

Age

0.992

0.959 - 1.025

0.6206

Sex

1.371

0.556 - 3.381

0.4933

Race

1.567

0.646 - 3.798

0.3206

Duration of observation

0.787

0.477 - 1.298

0.3486

Duration of disease

1.001

0.945 - 1.059

0.9828