Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 7, Number 5-6, December 2014, pages 131-136


Assessment of Growth and Development in Children With Hepatitis B Positivity

Tables

Table 1. Normal Values and Laboratory Procedures
 
ParametersCutoff pointsMethod
AST (U/L)Colorimetric
  1 - 9 years15 - 55
  10 - 19 years5 - 45
ALT (U/L)Colorimetric
  1 - 19 years5 - 45
GGT (U/L)Colorimetric
  4 months - 10 years5 - 32
  10 - 15 years5 - 24
ALP (U/L)Colorimetric
  < 15 years350 - 1,000
  > 15 years25 - 250
Total bilirubin (mg/dL)0.2 - 1.3Colorimetric
AFP (ng/mL)0 - 14Chemiluminescence
IGF-1 (ng/mL)Enzymatic-labeled chemiluminescent immunometric assay
  0 - 4 years49 - 171
  > 4 years76 - 499
IGFBP-3 (ng/mL)Enzymatic-labeled chemiluminescent immunometric assay
  5 - 10 years1.1 - 7
  10 - 15 years2.4 - 9.5
HBV DNA (IU/mL)Polymerase chain reaction
  Positive< 2,000
  Negative> 2,000
HAI scoreKnodell scoring system
  Minimal inflammation1 - 4
  Mild-marked inflammation> 4

 

Table 2. Features of Children Diagnosed With Hepatitis B
 
Age
  Mean age10.81 ± 3.23
  Age range2 - 16.49
SDS for height-0.29 ± 0.88 (-2.15 - 1.47)
SDS for weight-0.30 ± 0.99 (-2.52 - 1.67)
SDS for BMI-0.25 ± 1.25 (-4.83 - 1.89)
Gender
  Girl17 (39.5%)
  Boy26 (60.5%)
Potential way of contamination
  Circumcision at home1 (2.3%)
  Operation3 (7%)
  Dental treatment3 (7%)
  Hospitalization1 (2.3%)
Family history of hepatitis B
  Yes37 (86%)
  No6 (14%)
Follow-up (month)2 - 84
  Mean35.16 ± 24.8
Treated6 (14%)
  Lamivudine5 (11.6%)
  Adefovir1 (2.3%)
  Previously received interferon + lamivudine1 (2.3%), maintenance with lamivudine
  Not treated37 (86%)

 

Table 3. Laboratory Findings of Patients
 
Mean ± SD
AST (U/L)12 - 66 (35.2 ± 11.1)
ALT (U/L)9 - 113 (37.6 ± 21)
GGT (U/L)6 - 29 (11.7 ± 3.8)
ALP (U/L)71 - 491 (259.27 ± 81.06)
Total bilirubin (mg/dL)0.2 - 1.3 (0.22 ± 0.1)
Direct bilirubin (mg/dL)0.1 - 0.5 (0.22 ± 0.1)
AFP (IU/mL)0 - 5.4 (1.5 ± 1.14)
IGF-1 SDS (ng/mL)-2.27 - 6.81 (0.5 ± 1.94)
IGFBP-3 SDS (ng/mL)-3.83 - 2.59 (0.16 ± 1.40)

 

Table 4. Comparison of Mean Laboratory Findings of Children With or Without Malnutrition
 
Malnutrition (+)Malnutrition (-)P value
*Malnutrition was detected in only one child who underwent biopsy, and HAI was found to be 6. **IGF-1 level was studied in 32 patients, and IGFBP-3 level was studied in 33 patients.
AST (U/L)41.09 ± 13.3133.25 ± 9.750.04
ALT (U/L)43.45 ± 31.5935.59 ± 16.630.297
GGT (U/L)10.72 ± 4.3112.09 ± 3.680.316
HAI score6*5.6 ± 2.80.905
HBV DNA (IU/mL)1 × 108 ± 8 × 1077 × 107 ± 6 × 1070.223
IGF-1 SDS (ng/mL)**-0.87 ± 0.840.8 ± 20.031
IGFBP-3 SDS (ng/mL)**-0.53 ± 0.930.35 ± 1.460.13