Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Review

Volume 7, Number 2, April 2014, pages 51-55

Alicaforsen: An Emerging Therapeutic Agent for Ulcerative Colitis and Refractory Pouchitis

Figures

Figure 1.
Figure 1. Cascade of events in the inflammatory process.
Figure 2.
Figure 2. Mechanism of action of alicaforsen.

Table

Table 1. Studies Analyzing the Use of Alicaforsen in Pouchitis and Ulcerative Colitis
 
ReferencesYearNumber of patientsResults
PouchitisUlcerative colitis
Miner et al [7]20041258% remissionN/A
Van Deventer et al [16]200440N/A70% improvement in disease activity index
Miner et al [21]2006105N/A24% complete mucosal healing in 240 mg Alicaforsen group
Miner et al [20]200615N/A46% improvement in disease activity index, 33% rate of remission
Van Deventer et al [12]2006112N/ALow relapse rate