Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 6, Number 5, October 2013, pages 191-199

Clinical Significance of Plasma Osteopontin Level as a Biomarker of Hepatocellular Carcinoma

Figures

Figure 1.
Figure 1. Figure 1. Plasma osteopontin levels in three groups. Box plots represent median, quartiles and extremes, the asterisks represent outliers.
Figure 2.
Figure 2. Figure 2. Serum AFP levels in different groups. Box plots represent median, quartiles and extremes, the asterisks represent outliers.
Figure 3.
Figure 3. Receiver operating characteristics (ROC) curve analysis of plasma OPN in comparison with AFP for discrimination between groups 1 and the other 2 groups.
Figure 4.
Figure 4. Direct significant correlation between plasma OPN and serum AFP level of the patient as serum AFP level increases with increase of osteopontin level.

Tables

Table 1. OPN Levels of all the Studied Patients Versus Various Clinical Parameters (n = 60)
 
Clinico-pathological featuresNoOsteopontin ng/dLP-value
Sex
  male52136 (79 - 189)0.55
  female18104 (54 - 221)
Hematem5178 (65 - 560)0.54
Cirrhosis57148 (90 - 207)0.00
Ascites40171 (115 - 303)0.00
Liver1
  Enlarged36140 (83 - 193)0.001
  Normal139 (33 - 44)
Tumor Size
  < 3 cm12140 (100 - 336)0.28
  ≥ 3 cm8229 (131 - 438)
Multiplicity
  Single19138 (97 - 178)0.00
  Multiple11495 (388 - 717)

 

Table 2. Correlations Between OPN and AFP and Other Parameters for all Studied Patients
 
OPNAFP
rPrP
Age (y)0.4480.0000.4760.000
AST (IU/L)0.4550.0000.4350.000
ALT (IU/L)0.3280.0060.1710.158
Alb (g/dL)-0.6140.000-0.2740.017
T.Bil. (mg/dL)-.4520.0000.2820.018
PC%-0.330.005-0.310.009
Hb (gm/dL)-0.130.268-0.070.95
Plat. (× 103/mm3)-0.330.004-0.430.000
AFP (ng/mL)0.4080.000

 

Table 3. Comparison of Alpha Fetoprotein and Osteopontin in the 3 Groups
 
Group I (n = 30)Group II (n = 30)Control (n = 10)P value
* P-value calculated by Kruskal-Wallis Test. P-value is significant if < 0.05. Groups having the same letters are not statistically significance.
AFP
   (ng/mL)		79 (38 - 726)
a		5.5 (4 - 10)
b		3.5 (3 - 4.4)
c		0.00*
OPN
   (ng/mL)		178 (116 - 410)
a		122.5 (73 - 173)
b		37.5 (33 - 44)
c		0.00*

 

Table 4. Diagnostic Sensitivity and Specificity of Plasma OPN Level of HCC Patients in Comparison With AFP for Selective Detection of HCC
 
Sensitivity (%)Specificity (%)Cut-off (ng/mL)
OPN73%54%128.5
AFP90%77%10.4