Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 5, Number 2, April 2012, pages 45-51

Warfarin Use During Fecal Occult Blood Testing: A Meta-Analysis

Figures

Figure 1.
Figure 1. Selection of studies for inclusion in the meta-analysis of warfarin use during fecal occult blood testing.
Figure 2.
Figure 2. Forest plot showing no statistically significant effect on colorectal cancer detection for FOBT obtained with warfarin versus without warfarin.
Figure 3.
Figure 3. Forest plot showing no statistically significant effect on advanced adenoma detection for FOBT obtained with warfarin versus without warfarin.
Figure 4.
Figure 4. Measure of publication bias using a funnel plot.

Tables

Table 1. Characteristics of Studies Included in Meta-Analysis
 
AuthorStudyBlindedLocationFOBTPatients (n)Study Quality ★
★ Stars based upon Newcastle-Ottawa quality assessment scale for cohort studies (0 stars = poor, 9 stars = excellent)
Bini et al - 2005CohortNoneUnited StatesHemoccult II420★★★★★★★★★
Iles-Shih et al - 2010CohortNoneUnited StatesHemoccult II9637★★★★★★★★★
Kershenbaum et al - 2010CohortNoneIsraelHemoccult Sensa425★★★★★★★★
Sawhney et al - 2010CohortNoneUnited StatesHemoccult II or equivalent603★★★★★★★★
Mandelli et al - 2010CohortNoneItalyiFOBT159★★★★★★★★

 

Table 2. Summary of the Analyses for FOBT Obtained With Warfarin Versus Without Warfarin for Colonoscopy Findings and Detection of Neoplasia or Any Adenoma
 
OutcomeOdds Ratio95% Confidence IntervalP-ValueI2
* Random effects model and an elimination analysis was performed given statistically significant heterogeneity.
Colonoscopic Findings0.880.48 - 1.620.6781%*
Neoplasia0.880.58 - 1.350.5776%*
Any Adenoma1.080.73 - 1.580.7123%