Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website http://www.gastrores.org

Original Article

Volume 4, Number 6, December 2011, pages 268-276

Coeliac Disease in the 21st Century: No Longer “Kids’ Stuff”

Figure 1. Age distribution of all celiac patients diagnosed in 2010 at two Spanish Hospitals; results show that CD predominates in adult patients between the 3rd and 5th decades of life.

**Table 1.** Comparative Characteristics of All Cases of Celiac Disease Diagnosed During the Year 2010 in Two General Hospitals in Spain. Data are Alternatively Expressed as Mean ± Standard Deviation, or Number of Patient and Percentage
	Adult CD patients	Paediatric CD patients
tTGA: anti-tissue transglutaminase antibodies; BMI: body mass index.
Number or patients (%)	20 (80%)	48 (88%)	0.29	5 (20%)	6 (11%)	0.29
Female / Male (%)	19/1 (95%)	31/17 (64.58%)	0.01	4/1 (80%)	3/3 (50%)	0.30
Mean age ± SD (years)	43.50 (13.89)	43.15 (15.90)	0.93	4.03 (5.02)	3.33 (2.94)	0.77
Positive tTGA (%)	5 (25%)	8 (16.7%)	0.50	4 (80%)	5 (83.3%)	0.89
BMI (in adults)	24.95 (6.38)	24.56 (3.62)	0.76	-	-	-
Diagnostic delay	127.53 (155.11)	52.90 (53.74)	0.39	15.20 (18.62)	7 (3.46)	0.66
Classic symptoms (%)	11 (55%)	26 (54.16%)	0.95	4 (80%)	6 (100%)	0.46
Haemoglobin levels (g/dL)	13.11 (1.52)	12.971 (2.19)	0.89	12.90 (0.85)	11.283 (0.96)	0.03
Serum Iron (µg/dL)	74.30 (29.95)	71.38 (50.76)	0.31	79.50 (24.20)	44 (7.92)	0.038
Ferritin (ng/mL)	62 (114.39)	49.40 (52.96)	0.65	25.20 (12.91)	20.83 (7.28)	0.66
Familiar association (%)	3 (15%)	6 (12.5%)	0.95	0 (0%)	3 (50%)	0.24
Marsh I	13 (65%)	32 (66.7%)	0.89	1 (20%)	0 (0%)	0.25
Marsh II	3 (15%)	7 (14.6%)	1	2 (40%)	1 (16.7%)	0.55
Marsh III (a, b, c)	4 (20%)	9 (18.7%)	1	2 (40%)	5 (83.3%)	0.24
DQ2 haplotype	15 (75%)	43 (89.6%)	0.14	4 (80%)	5 (83.3%)	1
DQ8 haplotype	2 (10%)	2 (4.2%)	0.58	1 (20%)	1 (16.7%)	1
Non DQ2/DQ8	3 (15%)	3 (6.2%)	0.35	0 (0%)	0 (0%)	1

Table 1. Comparative Characteristics of All Cases of Celiac Disease Diagnosed During the Year 2010 in Two General Hospitals in Spain. Data are Alternatively Expressed as Mean ± Standard Deviation, or Number of Patient and Percentage

Adult CD patients

Paediatric CD patients

Hospital #1

Hospital #2

Hospital #1

Hospital #2

tTGA: anti-tissue transglutaminase antibodies; BMI: body mass index.

Number or patients (%)

20 (80%)

48 (88%)

0.29

5 (20%)

6 (11%)

0.29

Female / Male (%)

19/1 (95%)

31/17 (64.58%)

0.01

4/1 (80%)

3/3 (50%)

0.30

Mean age ± SD (years)

43.50 (13.89)

43.15 (15.90)

0.93

4.03 (5.02)

3.33 (2.94)

0.77

Positive tTGA (%)

5 (25%)

8 (16.7%)

0.50

4 (80%)

5 (83.3%)

0.89

BMI (in adults)

24.95 (6.38)

24.56 (3.62)

0.76

Diagnostic delay

127.53 (155.11)

52.90 (53.74)

0.39

15.20 (18.62)

7 (3.46)

0.66

Classic symptoms (%)

11 (55%)

26 (54.16%)

0.95

4 (80%)

6 (100%)

0.46

Haemoglobin levels (g/dL)

13.11 (1.52)

12.971 (2.19)

0.89

12.90 (0.85)

11.283 (0.96)

0.03

Serum Iron (µg/dL)

74.30 (29.95)

71.38 (50.76)

0.31

79.50 (24.20)

44 (7.92)

0.038

Ferritin (ng/mL)

62 (114.39)

49.40 (52.96)

0.65

25.20 (12.91)

20.83 (7.28)

0.66

Familiar association (%)

3 (15%)

6 (12.5%)

0.95

0 (0%)

3 (50%)

0.24

Marsh I

13 (65%)

32 (66.7%)

0.89

1 (20%)

0 (0%)

0.25

Marsh II

3 (15%)

7 (14.6%)

2 (40%)

1 (16.7%)

0.55

Marsh III (a, b, c)

4 (20%)

9 (18.7%)

2 (40%)

5 (83.3%)

0.24

DQ2 haplotype

15 (75%)

43 (89.6%)

0.14

4 (80%)

5 (83.3%)

DQ8 haplotype

2 (10%)

2 (4.2%)

0.58

1 (20%)

1 (16.7%)

Non DQ2/DQ8

3 (15%)

3 (6.2%)

0.35

0 (0%)

**Table 2.** Comparative Characteristics of All Cases of Celiac Disease Diagnosed During the Year 2010 in Two General Hospitals in Spain. Data are Alternatively Expressed as Mean ± Standard Deviation, or Number of Patient and Percentage
	Adult patients	Paediatric patients	p
tTGA: anti-tissue transglutaminase antibodies; BMI: body mass index.
Number or patients (%)	68 (86.1%)	11 (13.9%)	-
Female / Male (%)	50/18 (73.53%)	7/4 (63.64%)	0.49
Familiar association (%)	9 (13.2%)	3 (27.3%)	0.358
Positive tTGA (%)	13 (19.1%)	9 (81.8%)	0.004
Diagnostic delay (months)	70.67 ± 93	10.73 ± 12.77	< 0.001
Classic symptoms (%)	37 (54.4%)	10 (90.9%)	0.024
Haemoglobin levels (g/dL)	13.01 ± 2	12.02 ± 1.21	0.025
Serum Iron (µg/dL)	72.24 ± 45.43	58.20 ± 23.79	0.398
Ferritin (ng/mL)	53.16 ± 75.87	22.82 ± 9.92	0.245
Marsh I	45 (66.2%)	1 (9.1%)	< 0.001
Marsh II	10 (14.7%)	3 (27.3%)	0.38
Marsh III (a, b, c)	13 (19.1%)	7 (63.7%)	0.004
DQ2 haplotype	57 (85.1%)	8 (80%)	0.4
DQ8 haplotype	4 (6%)	2 (20%)	0.19
Non DQ2/DQ8	6 (9%)	0 (0%)	0.59

Table 2. Comparative Characteristics of All Cases of Celiac Disease Diagnosed During the Year 2010 in Two General Hospitals in Spain. Data are Alternatively Expressed as Mean ± Standard Deviation, or Number of Patient and Percentage

Adult patients

Paediatric patients

tTGA: anti-tissue transglutaminase antibodies; BMI: body mass index.

Number or patients (%)

68 (86.1%)

11 (13.9%)

Female / Male (%)

50/18 (73.53%)

7/4 (63.64%)

0.49

Familiar association (%)

9 (13.2%)

3 (27.3%)

0.358

Positive tTGA (%)

13 (19.1%)

9 (81.8%)

0.004

Diagnostic delay (months)

70.67 ± 93

10.73 ± 12.77

< 0.001

Classic symptoms (%)

37 (54.4%)

10 (90.9%)

0.024

Haemoglobin levels (g/dL)

13.01 ± 2

12.02 ± 1.21

0.025

Serum Iron (µg/dL)

72.24 ± 45.43

58.20 ± 23.79

0.398

Ferritin (ng/mL)

53.16 ± 75.87

22.82 ± 9.92

0.245

Marsh I

45 (66.2%)

1 (9.1%)

< 0.001

Marsh II

10 (14.7%)

3 (27.3%)

0.38

Marsh III (a, b, c)

13 (19.1%)

7 (63.7%)

0.004

DQ2 haplotype

57 (85.1%)

8 (80%)

0.4

DQ8 haplotype

4 (6%)

2 (20%)

0.19

Non DQ2/DQ8

6 (9%)

0 (0%)

0.59

**Table 3.** Main Symptoms and Frequencies in Adult-onset CD at the Time of Diagnosi
	No (%)
GORD: Gastroesophageal reflux disease.
Abdominal pain	29 (42.64 %)
Diarrhoea	25 (36.76 %)
Anaemia	16 (23.52 %)
Dyspepsia	11 (16.17 %)
GORD-related symptoms	10 (14.7 %)
Constipation	10 (14.7 %)
Vomiting	5 (7.35 %)
Weight loss	3 (4.41 %)
Dysphagia	3 (4.41 %)
Hypertransaminasemia	2 (2.94 %)
Hypocalcemia	1 (1.47 %)
Dermatitis	1 (1.47 %)

Table 3. Main Symptoms and Frequencies in Adult-onset CD at the Time of Diagnosi

No (%)

GORD: Gastroesophageal reflux disease.

Abdominal pain

29 (42.64 %)

Diarrhoea

25 (36.76 %)

Anaemia

16 (23.52 %)

Dyspepsia

11 (16.17 %)

GORD-related symptoms

10 (14.7 %)

Constipation

10 (14.7 %)

Vomiting

5 (7.35 %)

Weight loss

3 (4.41 %)

Dysphagia

3 (4.41 %)

Hypertransaminasemia

2 (2.94 %)

Hypocalcemia

1 (1.47 %)

Dermatitis

1 (1.47 %)