Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
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Original Article

Volume 4, Number 3, June 2011, pages 97-106

Povidone-Iodine Irrigation of Subcutaneous Tissues May Decrease Surgical Site Infections in Elective Colorectal Operations: A Systematic Review


Figure 1.
Figure 1. Systematic review PRISMA flow diagram.
Figure 2.
Figure 2. Forest plot of odds ratio for Povidone-Iodine treatment compared to controls.
Figure 3.
Figure 3. Forest plot of risk ratio for Povidone-Iodine treatment compared to controls.
Figure 4.
Figure 4. Methodological quality of included studies graph. Methodological quality graph: review authors’ judgments about each methodological quality item presented as percentages across all included studies.
Figure 5.
Figure 5. Methodological quality summary of included studies. Methodological quality summary: review authors’ judgments about each methodological quality item for each included study.
Figure 6.
Figure 6. Sensitivity analysis based on high methodological quality.
Figure 7.
Figure 7. Sensitivity analysis based on low methodological quality.


Table 1. Description of Studies Included in Systematic Review
Author, Year of StudyDesign, DurationTreatmentControlParticipantsOutcomes
Note: RCT = Randomized Control Trial; + = Number of wound infections; PVI = Povidone-Iodine
Gray, 1981RCT, 15 monthsPVI sprayNot sprayed43212144134Incidence of wound infection
Kothuis, 1981RCT, ?10% PVI solutionIodine tincture10194761145Wound healing
McCluskey, 1976RCT, ?10% PVI solutionNo solution24503650Incidence of infected wounds
Rogers, 1983RCT, 6 months10% PVI solutionNormal saline1244.252718.5Wound infection rate
Walsh, 1981RCT, 12 months5% PVI sprayNot sprayed3221481942(1) Incidence of wound infection
(2) Mean postoperative hospital stay
Totals5 RCTs3 solution; 2 spray3 non-Rx17101-36104-Variable


Table 2. Baseline Characteristics of Patients in Included Studies
Author, Year of StudyTotal number of patients# of patients included in SRAge
GenderOperative time (min)Preoperative antibiotics
(# of patients)
Postoperative antibiotics
(# of patients)
Note: SR = Systematic Review; M = Males; F = Females; min = minutes; N/A = not available
Gray, 19811537316 - 76698420 - 1054436
Kothuis, 19812203048 (mean)13288< 60 - 240
McCluskey, 19761101040 - 654664N/A
Rogers, 19831875160.2 (mean)
Walsh, 19816274143.4 (mean)31431313983