Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website http://www.gastrores.org

Original Article

Volume 4, Number 2, April 2011, pages 43-50

Implications of Serum 25-Hydroxyvitamin D on the Prevalence of Neoplastic Polyps: A Cross-Sectional Study

**Table 1.** Histological Classification of Polyps Evaluated for Colon Location
	All	Cecum	Ascending	Transverse	Descending	Sigmoid	Rectum
Hyperplastic	50 (29.8)	2 (10)	13 (35.2)	5 (26.3)	7 (24.1)	18 (41.9)	5 (25)
Tubular Adenoma	97 (57.7)	13 (65)	18 (48.6)	14 (73.7)	18 (62.1)	23 (53.5)	11 (55)
Villous Adenoma	1 (0.6)	1 (5)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Tubulovillous Adenoma	8 (4.7)	0 (0)	4 (10.8)	0 (0)	0 (0)	2 (4.6)	2 (10)
Malignant	6 (3.6)	3 (15)	0 (0)	0 (0)	1 (3.4)	0 (0)	2 (10)
Other	6 (3.6)	1 (5)	2 (5.4)	0 (0)	3 (10.4)	0 (0)	0 (0)
Totals	168 (100)	20 (11.9)	37 (22)	19 (11.3)	29 (17.3)	43 (25.6)	20 (11.9)

Table 1. Histological Classification of Polyps Evaluated for Colon Location

All

Cecum

Ascending

Transverse

Descending

Sigmoid

Rectum

N (%)

Hyperplastic

50 (29.8)

2 (10)

13 (35.2)

5 (26.3)

7 (24.1)

18 (41.9)

5 (25)

Tubular Adenoma

97 (57.7)

13 (65)

18 (48.6)

14 (73.7)

18 (62.1)

23 (53.5)

11 (55)

Villous Adenoma

1 (0.6)

1 (5)

0 (0)

Tubulovillous Adenoma

8 (4.7)

0 (0)

4 (10.8)

0 (0)

2 (4.6)

2 (10)

Malignant

6 (3.6)

3 (15)

0 (0)

1 (3.4)

0 (0)

2 (10)

Other

6 (3.6)

1 (5)

2 (5.4)

0 (0)

3 (10.4)

0 (0)

Totals

168 (100)

20 (11.9)

37 (22)

19 (11.3)

29 (17.3)

43 (25.6)

20 (11.9)

**Table 2.** Multivariate Analyses for Polyps, Adenomas, and 25(OH) Vitamin D Levels Adjusted for Race, Gender and Age
	Polyps	P Value	Adenoma	P Value	25(OH) vit-D	P Value
Race			0.541			0.816				0.000 (95%) CI
Caucasian	311 (72.5)	118 (27.5)		348 (81.1)	81 (18.9)		33 (7.7)	253 (59.0)	143 (33.3)
Black	99 (77.3)	29 (22.7)		105 (82.0)	23 (18.0)		29 (22.7)	84 (65.6)	15 (11.7)
Other	70 (74.5)	24 (25.5)		74 (78.7)	20 (21.3)		10 (10.6)	70 (74.5)	14 (14.9)
Gender			0.001 (95%) CI			0.009 (95%) CI				0.225 (95%) CI
Male	220 (67.9)	104 (32.1)		249 (76.9)	75 (23.1)		34 (10.5)	213 (65.7)	77 (23.8)
Female	260 (79.5)	67 (20.5)		278 (85)	49 (15)		38 (11.6)	194 (59.3)	95 (29.1)
Age			0.000 (95%) CI			0.001 (95%) CI				0.800 (95%) CI
< 30 yo	21 (95.5)	1 (4.5)		21 (95.5)	1 (4.5)		1 (4.5)	16 (72.7)	5 (22.7)
31 - 60 yo	319 (77.8)	91 (22.2)		345 (84.1)	65 (15.9)		48 (11.7)	255 (62.2)	107 (26.1)
> 60 yo	140 (63.9)	79 (36.1)		161 (73.5)	58 (26.5)		23 (10.5)	136 (62.1)	60 (27.4)

Table 2. Multivariate Analyses for Polyps, Adenomas, and 25(OH) Vitamin D Levels Adjusted for Race, Gender and Age

Polyps

P Value

Adenoma

P Value

25(OH) vit-D

P Value

< 10

10.1 - 30

> 30

Number (%)

ng/ml

Race

0.541

0.816

0.000 (95%) CI

Caucasian

311 (72.5)

118 (27.5)

348 (81.1)

81 (18.9)

33 (7.7)

253 (59.0)

143 (33.3)

Black

99 (77.3)

29 (22.7)

105 (82.0)

23 (18.0)

29 (22.7)

84 (65.6)

15 (11.7)

Other

70 (74.5)

24 (25.5)

74 (78.7)

20 (21.3)

10 (10.6)

70 (74.5)

14 (14.9)

Gender

0.001 (95%) CI

0.009 (95%) CI

0.225 (95%) CI

Male

220 (67.9)

104 (32.1)

249 (76.9)

75 (23.1)

34 (10.5)

213 (65.7)

77 (23.8)

Female

260 (79.5)

67 (20.5)

278 (85)

49 (15)

38 (11.6)

194 (59.3)

95 (29.1)

Age

0.000 (95%) CI

0.001 (95%) CI

0.800 (95%) CI

< 30 yo

21 (95.5)

1 (4.5)

21 (95.5)

1 (4.5)

16 (72.7)

5 (22.7)

31 - 60 yo

319 (77.8)

91 (22.2)

345 (84.1)

65 (15.9)

48 (11.7)

255 (62.2)

107 (26.1)

> 60 yo

140 (63.9)

79 (36.1)

161 (73.5)

58 (26.5)

23 (10.5)

136 (62.1)

60 (27.4)

**Table 3.** Relationship Between 25(OH) Vitamin D and Presence of Polyps
25(OH) vit D	Polyp N	Polyp Y	Total	P Value
< 10 ng/ml	54 (75.0)	18 (25.0)	72
10.1 - 30 ng/ml	303 (74.4)	104 (25.6)	407
> 30 ng/ml	123 (71.5)	49 (28.5)	172
Totals	480 (73.7)	171 (26.3)	651	0.739

Table 3. Relationship Between 25(OH) Vitamin D and Presence of Polyps

25(OH) vit D

Polyp N

Polyp Y

Total

P Value

Number (%)

Number

(Chi-Square)

< 10 ng/ml

54 (75.0)

18 (25.0)

10.1 - 30 ng/ml

303 (74.4)

104 (25.6)

407

> 30 ng/ml

123 (71.5)

49 (28.5)

172

Totals

480 (73.7)

171 (26.3)

651

0.739

**Table 4.** Relationship Between 25(OH) Vitamin D and Adenoma
25(OH) vit D	Adenoma N	Adenoma Y	Total	P Value
< 10 ng/ml	62 (86.1)	10 (13.9)	72
10.1 - 30 ng/ml	326 (80.1)	81 (19.9)	407
> 30 ng/ml	139 (80.8)	33 (19.2)	172
Totals	527 (81.0)	124 (19.0)	651	487

Table 4. Relationship Between 25(OH) Vitamin D and Adenoma

25(OH) vit D

Adenoma N

Adenoma Y

Total

P Value

Number (%)

Number

(Chi-Square)

< 10 ng/ml

62 (86.1)

10 (13.9)

10.1 - 30 ng/ml

326 (80.1)

81 (19.9)

407

> 30 ng/ml

139 (80.8)

33 (19.2)

172

Totals

527 (81.0)

124 (19.0)

651

487