Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 3, Number 3, June 2010, pages 101-105


A RecQ Protein-like 5 Haplotype is Associated With Colon Cancer

Tables

Table 1. Kentucky Colon Cancer Study Demographics
 
Variables, Mean (SD) or n (%)Cases (n = 390)Controls (n = 464)p-valuea
aStudent’s t-test or chi-square for differences, complete data on covariates available for 340 cases and 415 controls.
bUse at least twice per week ≥ 6 months.
Age, yr63.0 (10.5)58.1 (11.1)0.001
Male196 (50)170 (37)
Female194 (50)294 (63)0.001
Regular NSAID useb217 (64)290 (70)0.08
Family history of colorectal cancer86 (25)62 (15)0.001
Body mass index (kg/m2)29.2 (6.3)27.9 (5.8)0.002

 

Table 2. Allele and Genotype Frequencies and Association Tests for RECQL5 SNPs
 
SNPTotalGenotypeMAFAllele χ2, p-valueCrude OR (95% CI)Adjusted ORa (95% CI)
aPer allele odds ratios adjusted for age, sex, BMI, NSAID use and family history of colorectal cancer.
rs820196TTTCCCC
  Cases3900.580.360.060.240.27, 0.601.06 (0.85, 1.32)1.05 (0.83, 1.34)
  Controls4640.600.340.060.23
rs4789223AAAGGGG
  Cases3900.340.450.210.433.42, 0.071.19 (0.98, 1.43)1.21 (0.98, 1.49)
  Controls4640.380.460.160.39

 

Table 3. RECQL5 Colon Cancer Haplotype Association Tests
 
rs820196-rs4789223 haplotypeaCase frequencyControl frequencyOR (95% CI), p-valueAdjusted OR (95% CI),b p-value
aC-A haplotype too rare to consider; frequency of 0.001 in cases, absent in controls.
bAdjusted for age, sex, BMI, NSAID use and family history of colorectal cancer.
T-A (common alleles)0.570.611.0 (reference)1.0 (reference)
C-G (2 minor alleles)0.230.231.13 (0.83, 1.37), 0.621.13 (0.87, 1.47), 0.72
T-G0.200.161.34 (1.02, 1.76), 0.051.39 (1.04, 1.87), 0.04