Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
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Case Report

Volume 3, Number 3, June 2010, pages 139-143

Follicular Dendritic Cell Tumor in Liver: A Case Report and Collective Review


Figure 1.
Figure 1. (a) Enhanced abdominalCT of horizontal view which revealed huge hepatic hypervascular mass of about 14 cm in size (arrow). (b) Enhanced abdominalCT of coronal view which revealed huge hepatic hypervascular mass of about 14 cm in size.(arrow). (c) Angiography revealed the mass was mainly supplied by the left hepatic(arrow). (d) Macroscopic view of the resected follicular dendritic cell tumor of liver as a round softmass and on cut section shows whitish to pinkish surface without centralnecrosis.
Figure 2.
Figure 2. (a) Microscopic appearance of follicular dendritic cell tumor. At low magnification, the tumorcells in whorls pattern show hypechromatism and pleomorphism, and interspersedplasma cells and lymphocytes. Higher magnification demonstrates slight eosinophilic cytoplasm, rare mitosis, and indistinct cell borders with granular chromatin and small nucleoli. (b) Immunohistochemical staining for CD 21, the spindle-shaped tumor cells show long cytoplasmic processes which stain brownish. (c) Immunohistochemical staining for CD 35, a marker for follicular dendritic cells reveals tumor cells stained brownish. (d) Positive expression of EBV nuclear RNA on tumor cells by in situ hybridization.


Table 1. The Clinical Manifestation of Collective Cases With FDC Tumor
CaseAge (y/o)GenderClinical PresentationMaximal size (cm)EBVTreatmentReference
+: positive; -: negative; NA: Not available; *:the metastatic cases; EBV: Epstein-Barr Virus; #: well response to chemotherapy.
168FMalaise, weight loss, anemia11+Chemotherapy; partial hepatectomy[11]
235FEpigastric discomfort, fever, weight loss20+Right hemihepatectomy[5]
337MMalaise, weight loss15+Right trisegmentectomy with caudate lobectomy[16]
419FR't upper quadrant pain, weight loss, palpable abdominal mass12+Excision[18]
556FGastrointestinal upset15+Resection[18]
640FEpigastric pain, weight loss12.5+Left hepatectomy[18]
749FLiver mass on ultrasound during routine health check-up4.2+Excision[18]
831FAbdominal distention, weight loss15+Right hemihepatectomy[18]
957FEpigastralgia9.5+Right hemihepatectomy[17]
1051FAbdominal discomfort, weight loss12+Left lobectomy[18]
1130FLiver mass on ultrasound during routine health check-up5.5+Right lobectomy[19]
1282MLiver mass on abdominal CT scan during evaluation of renal calculi; weight loss, weakness10-Right lobectomy[21]
1357FAbdominal pain, dizziness, vomitingNA+Resection[4]
*1470MAbdominal pain, weight loss2.5-NA[6]
*1565FStaging workup showed lesion in liver from abdominal CT2NAResection[7]
*1619MRight upper quadrant pain16NAChemotherapy#[8]
1736FEpigastric discomfort14+Left Lateral segmental hepatectomyPresent case