Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 2, Number 6, December 2009, pages 338-343

Study of Chronic Hepatopathy in Patients With Sickle Cell Disease

Tables

Table 1. Demographic, Clinical and Ultrasonographic Characteristics of The Study Group
 
CharacteristicsNumber
Male/female112/58
Age (mean ± SD)26.3 ± 5.6
History of blood transfusion
  None11
  < 1078
  > 1081
Jaundice123
Hepatomegaly118
Ultrasonographic changes
  Hepatomegaly121
  Cirrhosis3
Cholelithiasis90
Cholecystectomy13

 

Table 2. Laboratory Parameters of the Study Group
 
Laboratory ParametersNo. of Patients
ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; Antinuclear antibody (ANA); Anti–smooth muscle antibody (ASMA); Anti–liver-kidney microsomal antibody (anti–LKM-1).
Abnormal liver function tests
  ALT (> 40 IU)27
  AST (> 45 IU)73
Bilirubin (> 2 mg/dL)123
  conjugated60
ALP (> 200IU)104
Albumin (< 3 gm/dL)0
Prothrombin time (sec.)19
Ferritin (ug/L)
  < 20043
  200 – 100069
  > 100058
HbsAg (+)18
HCV (+)39
anti-LKM-10
ANA2
ASMA2

 

Table 3. Histopathologic Findings of 27 Patients With Sickle Cell Disease
 
Patient NOKupffer cell hyper-plasiaSinusoidal dilatationSickling RBCErythroph-agocytosisChole-stasisMonouclear infiltrationIschemic necrosisPortal fibrosisHemoseder-osis
1++++No---yes-
2+++++No---No++
3+++++Yes+++No+
4++++++No++++yes+
5++++No+++-No+++
6++++No---No-
7+++No---No+
8+++++++No+++No+
9++++Yes++-No++
10++++++Yes-++yes+
11+++++No---No+++
12+++++Yes--+No+
13++++No++-No+
14++-No+--No++
15+++++++No++++++No+
16++-No---No++
17++++No-+-No-
18+++++No+++-+No+++
19++++No-+—No++
20++++No-+-No+
21++++Yes++-yes-
22+++++++Yes++-++No+
23+++No---No+
24+++++Yes+++No+
25++++No--+No+
26++++Yes+-+No+
27++-No---No++