Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 1, Number 1, December 2008, pages 33-39


Inhibition of de novo Methyltransferase 3B is a Potential Therapy for Hepatocellular Carcinoma

Figure

Figure 1.
Figure 1. Hierarchical clustering based on gene expression data from SMMC-7721 DNMT3B unsuppressed and suppressed cells, and SMMC-7721 5-Aza-CdR untreated and treated cells.

Tables

Table 1. Genes altered more than 2-fold after 5-Aza-CdR and pMT1 treatment in the hepatocellular carcinoma SMMC-7721 cell line.
 
GenBank_IDGene_Symbol5’CpG island (CGI)aFunction
aBased on a PubMed search; CGI, 5’ CpG island; None, no known 5’ CpG island.
Regulation of transcriptionNM_182917EIF4G1CGIregulation of translational initiation
Signal transductionNM_002733PRKAG1CGIregulates adipose differentiation
NM_004583RAB5CCGIsignal transduction, regulation
OthersNM_016219MAN1B1CGIhydrolase activity
NM_017883WDR13CGImRNA processing
NM_000526KRT14Noneepidermis development
NM_004860FXR2CGIinsulin receptor binding
NM_005993TBCDCGIintegrin-mediated signaling pathway
NM_000034ALDOACGIRNA binding

 

Table 2. Genes altered by more than 2.5-fold after pMT3B and 5-Aza-CdR treatment in the hepatocellular carcinoma cell line SMMC-7721
 
GenBank_IDSymbol5 CpG island (CGI)aFunction
aBased on a PubMed search; CGI, 5’ CpG island; None, no known 5’ CpG island.
Cell differentiation
  NM_006096NDRG1CGIcell differentiation
Cell proliferation
  NM_005557KRT16NOcell proliferation
  NM_013402FADS1CGIregulation of cell differentiation
Regulation of transcription
  NM_003926MBD3CGIregulation of transcription
  NM_005253FOSL2CGIregulation of transcription
Signal transduction
  NM_138769ARHT2CGIsignal transduction
  NM_004218RAB11BCGIsignal transduction
  NM_145173DIRAS1CGIsignal transduction
Others
  NM_017510HSGP25L2GCGIintracellular protein transport
  NM_006700FLN29CGInucleic acid binding
  NM_001956EDN2NOprotein kinase C activation
  NM_057089AP1S1CGIintracellular protein transport
  NM_020196XAB2CGIDNA repair
  NM_006412AGPAT2CGImetabolism
  NM_001074UGT2B7NOmetabolism
  NM_006247PPP5CCGIregulation of I-kappaB kinase/NF-kappaB cascade
  NM_002273KRT8NOcytoskeleton organization and biogenesis
  NM_006445PRPF8CGInuclear mRNA splicing, via spliceosome
  NM_002233KCNA4CGIpotassium ion transport
  NM_004204PIGQCGIcarbohydrate metabolism
  NM_004818DDX23CGIprotein kinase C activation
  NM_017458MVPNOresponse to drug
  NM_032038SPINLCGItetracycline transport
  NM_020230PPANCGIRNA splicing
  NM_001897CSPG4CGIcell motility
  NM_021979HSPA2NOmale meiosis
  NM_018110DOK4CGIinsulin receptor binding
  NM_144568C14orf9CGIhydrolase activity