Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website https://www.gastrores.org

Original Article

Volume 15, Number 6, December 2022, pages 334-342

Hospitalization Outcomes of Acute Pancreatitis in Hematopoietic Stem Cell Transplant Recipients

Figure 2. Categorical outcomes in total hospitalized patients with HSCT, stratified by the presence of acute pancreatitis. *Statistically significant outcomes.

**Table 1.** Patient Characteristics and Hospital Demographics of Patients With Hematopoietic Stem Cell Transplantation, Stratified by the Presence of Acute Pancreatitis
	Without pancreatitis	With pancreatitis	P-value
Age category			< 0.001
18 - 45	30,045 (21.57)	360 (42.11)
45 - 65	63,845 (45.84)	330 (38.6)
> 65	45,385 (32.59)	165 (19.3)
Sex			0.2574
Male	79,465 (57.06)	450 (52.6)
Female	59,810 (42.94)	405 (47.4)
Race			0.3758
White	97,105 (69.72)	540 (63.16)
African American	17,020 (12.22)	140 (16.37)
Hispanic	14,695 (10.55)	110 (12.87)
Asian/Pacific islander	4,405 (3.16)	35 (4.09)
Native American	475 (0.34)	0 (0)
Other	5,575 (4.00)	30 (3.51)
Insurance			0.0491
Medicare	53,505 (38.42)	260 (30.41)
Medicaid	15,735 (11.3)	180 (21.05)
Private	64,080 (46.01)	365 (42.69)
Underinsured	1,485 (1.07)	25 (2.92)
Income			0.2693
Lowest quartile	28,760 (20.65)	190 (22.22)
Second quartile	32,890 (23.62)	235 (27.49)
Third quartile	37,755 (27.11)	175 (20.47)
Highest quartile	39,870 (28.63)	255 (29.82)
Region			0.4801
Northeast	29,355 (21.08)	220 (25.73)
Midwest	34,535 (24.8)	185 (21.64)
South	46,580 (33.44)	285 (33.33)
West	28,805 (20.68)	165 (19.3)
Hospital location			0.0575
Rural	2,960 (2.13)	35 (4.09)
Urban	136,315 (97.85)	820 (95.91)
Hospital teaching status			< 0.001
Non-teaching hospitals	14,070 (10.1)	170 (19.88)
Teaching hospitals	125,205 (89.9)	685 (80.12)
Hospital bed size			0.007
Small	18,035 (12.95)	120 (14.04)
Medium	24,680 (17.72)	230 (26.9)
Large	96,560 (69.33)	505 (59.06)
Charlson comorbidities			0.0001
0	12,480 (8.96)	135 (15.79)
1	7,470 (5.36)	85 (9.94)
2	56,840 (40.81)	255 (29.82)
> 3	62485 (44.86)	380 (44.44)

Table 1. Patient Characteristics and Hospital Demographics of Patients With Hematopoietic Stem Cell Transplantation, Stratified by the Presence of Acute Pancreatitis

Without pancreatitis

With pancreatitis

P-value

Age category

< 0.001

18 - 45

30,045 (21.57)

360 (42.11)

45 - 65

63,845 (45.84)

330 (38.6)

> 65

45,385 (32.59)

165 (19.3)

Sex

0.2574

Male

79,465 (57.06)

450 (52.6)

Female

59,810 (42.94)

405 (47.4)

Race

0.3758

White

97,105 (69.72)

540 (63.16)

African American

17,020 (12.22)

140 (16.37)

Hispanic

14,695 (10.55)

110 (12.87)

Asian/Pacific islander

4,405 (3.16)

35 (4.09)

Native American

475 (0.34)

0 (0)

Other

5,575 (4.00)

30 (3.51)

Insurance

0.0491

Medicare

53,505 (38.42)

260 (30.41)

Medicaid

15,735 (11.3)

180 (21.05)

Private

64,080 (46.01)

365 (42.69)

Underinsured

1,485 (1.07)

25 (2.92)

Income

0.2693

Lowest quartile

28,760 (20.65)

190 (22.22)

Second quartile

32,890 (23.62)

235 (27.49)

Third quartile

37,755 (27.11)

175 (20.47)

Highest quartile

39,870 (28.63)

255 (29.82)

Region

0.4801

Northeast

29,355 (21.08)

220 (25.73)

Midwest

34,535 (24.8)

185 (21.64)

South

46,580 (33.44)

285 (33.33)

West

28,805 (20.68)

165 (19.3)

Hospital location

0.0575

Rural

2,960 (2.13)

35 (4.09)

Urban

136,315 (97.85)

820 (95.91)

Hospital teaching status

< 0.001

Non-teaching hospitals

14,070 (10.1)

170 (19.88)

Teaching hospitals

125,205 (89.9)

685 (80.12)

Hospital bed size

0.007

Small

18,035 (12.95)

120 (14.04)

Medium

24,680 (17.72)

230 (26.9)

Large

96,560 (69.33)

505 (59.06)

Charlson comorbidities

0.0001

12,480 (8.96)

135 (15.79)

7,470 (5.36)

85 (9.94)

56,840 (40.81)

255 (29.82)

> 3

62485 (44.86)

380 (44.44)

**Table 2.** Complications Related to HSCT and Acute Pancreatitis in HSCT Patients, Stratified by the Presence of AP
	Without pancreatitis	With pancreatitis	P-value
^aValues less than 11, not to be reported as per HCUP data user agreement (DUA). AP: acute pancreatitis; HSCT: hematopoietic stem cell transplantation; HLH: hemophagocytic lymphohistiocytosis; ERCP: endoscopic retrograde cholangiopancreatography.
Etiologies/complications related to HSCT
Myelodysplastic syndrome	9,375 (6.73)	50 (5.85)	0.641
Lymphoid leukemia	11,595 (8.33)	120 (14.04)	0.009
Myeloid leukemia	26,095 (18.74)	155 (18.13)	0.842
Hodgkin’s lymphoma	4,430 (3.18)	20 (2.34)	0.532
Non-Hodgkin’s lymphoma	3,505 (2.52)	15 (1.75)	0.526
Bone marrow failure	30 (0.02)	0 (0)	0.846
HLH	290 (0.21)	0 (0)	0.569
Thalassemia	290 (0.21)	0 (0)	0.57
Sickle cell	1,590 (1.14)	25 (2.92)	0.061
Metabolism error	210 (0.15)	0 (0)	0.639
Primary immunodeficiency	5,710 (4.1)	35 (4.09)	0.997
Graft-versus-host disease	19,390 (13.92)	185 (21.64)	0.005
Hemolytic uremic syndrome	130 (0.09)	0 (0)	0.726
Conditions related to acute pancreatitis
Cholangitis	660 (0.47)	55 (6.43)	< 0.001
Choledocholithiasis	1,680 (1.21)	135 (15.79)	< 0.001
Other biliary disorders	1,680 (1.21)	55 (6.43)	< 0.001
Hypertriglyceridemia	1,025 (0.74)	90 (10.53)	< 0.001
Hypercalcemia	2,025 (1.45)	25 (2.92)	0.112
Systemic lupus erythematosus	455 (0.33)	^a	0.057
Diabetic ketoacidosis	255 (0.18)	25 (2.92)	< 0.001
Cystic fibrosis	50 (0.04)	0 (0)	0.843
Alcohol use	1,805 (1.3)	50 (5.85)	< 0.001
Abdominal trauma	225 (0.16)	0 (0)	0.607
Anomalies of the pancreas	0 (0)	20 (2.34)	< 0.001
Percutaneous biliary procedures	25 (0.02)	0 (0)	0.881
ERCP	285 (0.2)	60 (7.02)	< 0.001

Table 2. Complications Related to HSCT and Acute Pancreatitis in HSCT Patients, Stratified by the Presence of AP

Without pancreatitis

With pancreatitis

P-value

^aValues less than 11, not to be reported as per HCUP data user agreement (DUA). AP: acute pancreatitis; HSCT: hematopoietic stem cell transplantation; HLH: hemophagocytic lymphohistiocytosis; ERCP: endoscopic retrograde cholangiopancreatography.

Etiologies/complications related to HSCT

Myelodysplastic syndrome

9,375 (6.73)

50 (5.85)

0.641

Lymphoid leukemia

11,595 (8.33)

120 (14.04)

0.009

Myeloid leukemia

26,095 (18.74)

155 (18.13)

0.842

Hodgkin’s lymphoma

4,430 (3.18)

20 (2.34)

0.532

Non-Hodgkin’s lymphoma

3,505 (2.52)

15 (1.75)

0.526

Bone marrow failure

30 (0.02)

0 (0)

0.846

HLH

290 (0.21)

0 (0)

0.569

Thalassemia

290 (0.21)

0 (0)

0.57

Sickle cell

1,590 (1.14)

25 (2.92)

0.061

Metabolism error

210 (0.15)

0 (0)

0.639

Primary immunodeficiency

5,710 (4.1)

35 (4.09)

0.997

Graft-versus-host disease

19,390 (13.92)

185 (21.64)

0.005

Hemolytic uremic syndrome

130 (0.09)

0 (0)

0.726

Conditions related to acute pancreatitis

Cholangitis

660 (0.47)

55 (6.43)

< 0.001

Choledocholithiasis

1,680 (1.21)

135 (15.79)

< 0.001

Other biliary disorders

1,680 (1.21)

55 (6.43)

< 0.001

Hypertriglyceridemia

1,025 (0.74)

90 (10.53)

< 0.001

Hypercalcemia

2,025 (1.45)

25 (2.92)

0.112

Systemic lupus erythematosus

455 (0.33)

0.057

Diabetic ketoacidosis

255 (0.18)

25 (2.92)

< 0.001

Cystic fibrosis

50 (0.04)

0 (0)

0.843

Alcohol use

1,805 (1.3)

50 (5.85)

< 0.001

Abdominal trauma

225 (0.16)

0 (0)

0.607

Anomalies of the pancreas

0 (0)

20 (2.34)

< 0.001

Percutaneous biliary procedures

25 (0.02)

0 (0)

0.881

ERCP

285 (0.2)

60 (7.02)

< 0.001

**Table 3.** Patient Characteristics and Hospital Demographics of Patients With Hematopoietic Stem Cell Transplantation, Stratified by the Presence of Acute Pancreatitis
	Without pancreatitis	With pancreatitis	P-value
^aValues less than 11, not to be reported as per HCUP DUA. A complete table of complications related to HSCT and pancreatitis is not presented due to number of patients for the majority of the categories being less than 11.
Age category			0.0089
18 - 45	3,795 (28.94)	70 (56.00)
45 - 65	6,050 (46.13)	35 (28.00)
> 65	3,270 (24.93)	20 (16.00)
Sex			0.139
Male	7,330 (55.89)	40 (32)
Female	5785 (44.11)	85 (68)
Race			0.5248
White	8,620 (65.73)	65 (52.00)
African American	1,375 (10.48)	25 (20.00)
Hispanic	1,660 (12.66)	25 (20.00)
Asian/Pacific islander	645 (4.77)	^a
Native American	40 (0.31)	0 (0)
Other	795 (6.06)	^a
Insurance			0.4607
Medicare	3,450 (26.31)	30 (24.00)
Medicaid	1,810 (13.80)	40 (32.00)
Private	7,215 (55.01)	50 (40.00)
Underinsured	95 (0.72)	0 (0)
Income			0.603
Lowest quartile	2,675 (20.40)	30 (24.00)
Second quartile	2,875 (21.92)	30 (24.00)
Third quartile	3,590 (27.37)	20 (16.00)
Highest quartile	3,975 (30.31)	45 (36.00)
Region			0.0765
Northeast	3,125 (23.83)	55 (44.00)
Midwest	2,800 (21.35)	20 (16.00)
South	3,930 (29.97)	20 (16.00)
West	3,260 (24.86)	30 (24.00)
Hospital location			0.6051
Rural	^a	0 (0)
Urban	13,105 (99.92)	125 (100.00)
Hospital teaching status			0.0003
Non-teaching hospitals	255 (1.94)	^a
Teaching hospitals	12,860 (98.06)	120 (96.00)
Hospital bed size			0.1696
Small	1,380 (10.52)	^a
Medium	2,105 (16.05)	30 (24.00)
Large	9,630 (73.43)	90 (72.00)
Charlson comorbidities
0	1,540 (11.74)	^a
1	580 (4.43)	^a
2	5,540 (42.24)	50 (40)
> 3	5,455 (41.59)	60 (48)

Table 3. Patient Characteristics and Hospital Demographics of Patients With Hematopoietic Stem Cell Transplantation, Stratified by the Presence of Acute Pancreatitis

Without pancreatitis

With pancreatitis

P-value

^aValues less than 11, not to be reported as per HCUP DUA. A complete table of complications related to HSCT and pancreatitis is not presented due to number of patients for the majority of the categories being less than 11.

Age category

0.0089

18 - 45

3,795 (28.94)

70 (56.00)

45 - 65

6,050 (46.13)

35 (28.00)

> 65

3,270 (24.93)

20 (16.00)

Sex

0.139

Male

7,330 (55.89)

40 (32)

Female

5785 (44.11)

85 (68)

Race

0.5248

White

8,620 (65.73)

65 (52.00)

African American

1,375 (10.48)

25 (20.00)

Hispanic

1,660 (12.66)

25 (20.00)

Asian/Pacific islander

645 (4.77)

Native American

40 (0.31)

0 (0)

Other

795 (6.06)

Insurance

0.4607

Medicare

3,450 (26.31)

30 (24.00)

Medicaid

1,810 (13.80)

40 (32.00)

Private

7,215 (55.01)

50 (40.00)

Underinsured

95 (0.72)

0 (0)

Income

0.603

Lowest quartile

2,675 (20.40)

30 (24.00)

Second quartile

2,875 (21.92)

30 (24.00)

Third quartile

3,590 (27.37)

20 (16.00)

Highest quartile

3,975 (30.31)

45 (36.00)

Region

0.0765

Northeast

3,125 (23.83)

55 (44.00)

Midwest

2,800 (21.35)

20 (16.00)

South

3,930 (29.97)

20 (16.00)

West

3,260 (24.86)

30 (24.00)

Hospital location

0.6051

Rural

0 (0)

Urban

13,105 (99.92)

125 (100.00)

Hospital teaching status

0.0003

Non-teaching hospitals

255 (1.94)

Teaching hospitals

12,860 (98.06)

120 (96.00)

Hospital bed size

0.1696

Small

1,380 (10.52)

Medium

2,105 (16.05)

30 (24.00)

Large

9,630 (73.43)

90 (72.00)

Charlson comorbidities

1,540 (11.74)

580 (4.43)

5,540 (42.24)

50 (40)

> 3

5,455 (41.59)

60 (48)