Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website https://www.gastrores.org

Review

Volume 15, Number 1, February 2022, pages 1-12

Statin Use in Patients With Chronic Liver Disease and Cirrhosis: Current Evidence and Future Directions

Figures

Figure 1.
Figure 1. Effects of statin use on portal hypertension and inflammatory response. eNOS: endothelial nitric oxide synthase; IL: interleukin; IFN: interferon; KLF2: Kruppel-like factor 2; TNF: tumor necrosis factor.
Figure 2.
Figure 2. Regulation of Rac1/KLF2 pathway by statins in hepatic stellate cells. HMG-CoA: 3-hydroxy-3-methylglutaryl coenzyme A; KLF2: Kruppel-like factor 2.
Figure 3.
Figure 3. (a) RhoA/Rho-kinase pathway in hepatic stellate cells. (b) Regulation of RhoA/Rho-kinase pathway by statins in hepatic stellate cells. HMG-CoA: 3-hydroxy-3-methylglutaryl coenzyme A; RhoA: Ras homolog gene family member A.