Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website https://www.gastrores.org

Original Article

Volume 14, Number 4, August 2021, pages 214-219


The Role of Clinical Characteristics in Stratifying Sedation Risk: A Cohort Study

Tables

Table 1. Demographics and ASA Classification for All Patients
 
MAC, n (%)Sedation, n (%)P value (Bonferroni corrected)
N = 1,180N = 853
MAC: monitored anesthesia care; ASA: American Society of Anesthesiologists; PolySUD: polysubstance use disorder.
Gender
  Male674 (66.2)390 (33.8)P < 0.001
  Female506 (52.2)463 (47.8)
Age
  Age < 1847 (88.7)6 (11.3)P < 0.001
  Age 18 - 40145 (60.4)77 (39.6)
  Age 41 - 60459 (58.8)321 (41.2)
  Age 60+529 (54.1)449 (45.9)
ASA
  ASA I198 (77.0)69 (23.0)P < 0.001
  ASA II525 (38.9)824 (61.1)
  ASA III128 (33.6)253 (66.4)
  ASA IV2 (5.6)34 (94.4)
Alcohol abuse354 (60.2)234 (39.8)0.10
Opioid abuse178 (62.9)105 (37.1)0.04
PolySUD203 (73.6)73 (26.4)P < 0.001
Psychiatric diagnosis815 (75.1)270 (24.9)P < 0.001

 

Table 2. Multivariate Regression of Anesthetic Choice as a Function of the Identified Clinical Characteristics
 
Odds ratio (95% CI)P values
CI: confidence interval; PolySUD: polysubstance use disorder; ASA: American Society of Anesthesiologists.
Age0.984 (0.978 - 0.990)P < 0.001
Sex0.644 (0.524 - 0.790)P < 0.001
Alcohol abuse1.29 (1.02 - 1.65)0.04
Opioid abuse0.778 (0.568 - 1.06)0.12
PolySUD1.54 (1.11 - 2.13)0.01
Psychiatric diagnosis4.66 (3.67 - 5.90)P < 0.001
ASA status1.03 (0.821 - 1.28)0.82

 

Table 3. Substance Abuse Rates and Psychiatric Comorbidity for ASA II Patients
 
Conscious sedation, n (%)MAC, n (%)P value (Bonferroni corrected)
N = 525N = 824
ASA: American Society of Anesthesiologists; MAC: monitored anesthesia care; PolySUD: polysubstance use disorder.
Alcohol abuse104 (19.8)172 (20.9)0.05
Opioid abuse25 (4.8)92 (11.2)P < 0.001
PolySUD19 (3.6)100 (12.1)P < 0.001
Psychiatric diagnosis140 (26.7)528 (64.1)P < 0.001

 

Table 4. Subset Analysis of ASA II Patients Who Received MAC Only Versus Those Who Received MAC After Previously Failing Moderate Sedation (MS)
 
MAC, post-MS failure, n (%)MAC only, n (%)P value (Bonferroni corrected)
N = 649N = 175
ASA: American Society of Anesthesiologists; MAC: monitored anesthesia care; PolySUD: polysubstance use disorder.
Alcohol abuse178 (27.4)24 (13.7)P < 0.001
Opioid abuse75 (11.6)17 (9.7)0.004
PolySUD72 (11.1)28 (16.0)P < 0.001
Psychiatric diagnosis423 (65.2)105 (60.0)P < 0.001