Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website https://www.gastrores.org

Original Article

Volume 14, Number 4, August 2021, pages 209-213


The Roles of Fibrosis Index Based on Four Factors and Aspartate Transaminase-to-Platelet Ratio Index Scoring Systems as an Alternative to Transient Elastography Liver Stiffness in Liver Fibrosis Staging in Human Immunodeficiency Virus and Hepatitis C Virus Co-Infected Patients

Tables

Table 1. Baseline and Clinical Characteristics of the Study Population (n = 344)
 
Characteristics
SD: standard deviation; TE-LS: transient elastography liver stiffness; APRI: aspartate transaminase-to-platelet ratio index; FIB-4: fibrosis index based on four factors.
Baseline characteristics
  Age (average ± SD)56.16 ± 10.46
  Gender
    Male234
    Female100
    Not disclosed10
Clinical characteristics
  Alanine aminotransferase (normal range 9 - 46 U/L) (median ± interquartile range)21 ± 16.75
  Aspartate aminotransferase (normal range 10 - 36 U/L) (median ± interquartile range)23 ± 11
  Platelets (normal range 150 - 450 × 103/µL) (median ± interquartile range)216 ± 83
  TE-LS (median ± interquartile range)5.4 ± 2.6
  Stages of liver cirrhosis according to TE-LS, n/N (%)
    F0-1 (< 7 kPa)285/344 (82.8%)
    F2 (7 - 8.9 kPa)16/344 (4.7%)
    F3 (9 - 11.9 kPa)14/344 (4.1%)
    F4 (≥ 12 kPa)29/344 (8.4%)
  APRI (median ± interquartile range)0.26 ± 0.17
    F0-10.26 ± 0.15
    F20.25 ± 0.17
    F30.32 ± 0.32
    F40.54 ± 0.62
  FIB-4 (median ± interquartile range)1.31 ± 0.91
    F0-11.27 ± 0.86
    F21.26 ± 1.37
    F31.67 ± 1.29
    F42.51 ± 2.08

 

Table 2. APRI Cutoff < 0.5 (No Cirrhosis) and ≥ 0.5 (Significant Fibrosis)
 
APRI: aspartate transaminase-to-platelet ratio index; PPV: positive predictive value; NPV: negative predictive value; AUC: area under the curve.
Sensitivity35.59%
Specificity91.23%
PPV45.65%
NPV87.25%
AUC0.2218

 

Table 3. FIB-4 Cutoff < 1.45 (No Cirrhosis) and ≥ 1.45 (Significant Fibrosis)
 
FIB-4: fibrosis index based on four factors; PPV: positive predictive value; NPV: negative predictive value; AUC: area under the curve.
Sensitivity64.41%
Specificity62.46%
PPV26.21%
NPV89.45%
AUC0.5098

 

Table 4. FIB-4 ≥ 1.45 (Significant Fibrosis) and APRI ≥ 0.5 (Significant Fibrosis)
 
FIB-4: fibrosis index based on four factors; APRI: aspartate transaminase-to-platelet ratio index; PPV: positive predictive value; NPV: negative predictive value; AUC: area under the curve.
Sensitivity50.00%
Specificity88.44%
PPV47.73%
NPV89.34%
AUC0.2183