Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 10, Number 5, October 2017, pages 288-293


Proton Pump Inhibitor Use Is Associated With an Increased Frequency of Hospitalization in Patients With Cystic Fibrosis

Figure

Figure 1.
Figure 1. Flowchart of initial screening for eligibility, exclusion and final number of patients included in analysis.

Tables

Table 1. Baseline Characteristics of Patients Hospitalized at Least Once in Year of Study and Non-Hospitalized Patients
 
Not hospitalized in past year (n = 55)Hospitalized at least once in past year (n = 59)P value
aPearson’s Chi-squared test (χ2). bMann-Whitney U test.
Male, % (n)54.5% (30)47.5% (28)0.449a
Age, median (range)30 (24 - 41)28 (24 - 35)0.315b
BMI, median (range)22 (20.4 - 26.5)20.2 (18.3 - 23.2)0.003b
Homozygous ΔF508, % (n)39.6% (21)61% (36)0.024a
ppFEV1, median (range)69% (53 - 81)40% (27 - 66)< 0.001b
Chronic pseudomonas colonization, % (n)65.4% (36)74.6% (44)0.287a
GER, % (n)65.4% (36)64.4% (38)0.907a
PPI use, % (n)50.9% (28)52.5% (31)0.862a
Pancreatic insufficiency, % (n)78.2% (43)83.1% (49)0.510a

 

Table 2. Baseline Characteristics of Proton Pump Inhibitor Users as Compared to Non-Users
 
No daily PPI (n = 55)Daily PPI (n = 59)P value
aPearson’s Chi-squared test (χ2). bMann-Whitney U test. cZero-inflated Poisson.
Male, % (n)60% (33)40% (25)0.06a
Age, median (range)29 (24 - 38)29 (24 - 34)0.519b
BMI, median (range)20.72 (19.15 - 23.72)21.35 (19.67 - 25.39)0.155b
F508 homozygous, % (n)55.6 (30)46.6 (27)0.341a
ppFEV1, median (range)57% (37 - 77)57% (32 - 75)0.932b
Pseudomonas, % (n)63.6% (35)76.3% (45)0.141a
Number of hospitalizations, mean ± SD0.9 ± 1.21.4 ± 2.10.009c
GER, % (n)30.9% (17)96.6% (57)< 0.001b
Pancreatic insufficiency, % (n)83.6% (46)77.9% (46)0.443a

 

Table 3. Zero-Inflated Poisson Regression Predicting Hospitalization for Pulmonary Exacerbation Over Year of Study
 
Number of hospitalizationsIRRRobust standard errorzP value95% confidence interval
PPI use1.750.4532.170.031.062.91
ppFEV10.980.007-2.840.0050.970.99
BMI1.010.0240.320.7510.961.06
Homozygous ΔF5081.380.3401.30.1950.852.23
Chronic pseudomonas colonization0.630.203-1.440.1490.331.18