Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 10, Number 5, October 2017, pages 301-304

Gastroesophageal Reflux Disease Associated With Anxiety: Efficacy and Safety of Fixed Dose Combination of Amitriptyline and Pantoprazole

Figure

Figure 1.
Figure 1. Mean change in anxiety symptom score.

Tables

Table 1. Evaluation of GERD Using the GERD Questionnaire
 
ParametersBaselineWeek 4Mean difference (95% confidence interval)Percent change (%)P value
Unpaired t-test
Heartburn2.823 ± 0.046820.9896 ± 0.02339-1.833 ± 0.0523364.96< 0.0001
Regurgitation2.156 ± 0.059840.125 ± 0.03393-2.031 ± 0.0687994.20
Pain2.771 ± 0.047940.5 ± 0.05339-2.271 ± 0.0717681.95
Nausea2.656 ± 0.057020.4167 ± 0.05058-2.24 ± 0.0762384.31
Sleep disturbance2.365 ± 0.049380.4792 ± 0.05125-1.885 ± 0.0711779.73
Additional medication2.719 ± 0.052780.4479 ± 0.05313-2.271 ± 0.0748983.52

 

Table 2. Evaluation of Physical and Mental Health Using SF-8 Questionnaire
 
ParametersBaselineWeek 4Mean change (95% confidence interval)Percent change (%)P value
Unpaired t-test.
General health3.969 ± 0.023194.948 ± 0.027180.9792 ± 0.0357324.64< 0.0001
Physical functioning4 ± 04.969 ± 0.017850.9688 ± 0.0178524.20
Role physical3 ± 03.74 ± 0.051820.7396 ± 0.0518224.66
Bodily pain3 ± 03.74 ± 0.045030.7396 ± 0.0450324.66
Vitality3 ± 03.74 ± 0.045030.7396 ± 0.0450324.66
Social functioning3 ± 03.74 ± 0.045030.7396 ± 0.0450324.66
Role emotional3 ± 03.74 ± 0.045030.7396 ± 0.0450324.66
Mental health3 ± 03.74 ± 0.045030.7396 ± 0.0450324.66