Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 8, Number 3-4, August 2015, pages 222-227

Immunogenicity of Recombinant Hepatitis B Vaccine Among Routinely Vaccinated Healthy and Chronically Ill Children in Assiut, Upper Egypt

Figure

Figure 1.
Figure 1. Correlation between age (in months) of the participating children and their Ab titer (r = -0.2; P = 0.0001).

Tables

Table 1. Distribution of Studied Children by Health Status
 
FrequencyPercent (%)
Normal13953
Renal failure3011.4
Diabetes mellitus124.6
Congenital heart diseases3714.1
Malnutrition186.9
Chronic liver diseases72.7
Chronic hemolytic anemias197.3
Total262100

 

Table 2. Distribution of Seroprevalence of HBsAb Titer by Health Status
 
Mean (mIU/mL)SD
Normal251.8386.5
Renal failure221.0409.7
Diabetes mellitus10.319.3
Congenital heart disease53.385.6
Malnutrition60.290.7
Chronic liver disease46.181.6
Chronic hemolytic anemias195.0470.8
Total186.4350.2

 

Table 3. Distribution of Antibody Titer by Age
 
AgeAntibody titer (mIU/mL)TotalP-value*
< 1010 - < 100≥ 100
*Significant.
One year or less (%)3(10.3)10 (34.5)16 (55.2)29 (100)0.05*
More than one year (%)83 (35.6)81 (34.8)69 (29.6)233 (100)
Total (%)86 (32.8)91(34.7)85 (32.5)262 (100)

 

Table 4. Comparing 5-Year Age Groups Regarding Antibody Titer
 
Mean difference95% CIP-value
*Significant.
Children < 5 years versus
  ≥ 5 years to < 10 years128.9818.56 - 239.390.022*
  ≥ 10 years169.4567.92 - 270.970.001*
Children ≥ 5 years to < 10 years versus ≥ 10 years40.47-87.48-168.420.534

 

Table 5. Comparing Antibody Titer Between Normal Children and Others With Different Diseases
 
Antibody titer (mIU/mL)Total, N (%)P-value
< 10, N (%)10 - < 100, N (%)≥ 100, N (%)
*Significant.
Normal34 (24.5)46 (33.1)59 (42.4)139 (100)
Renal failure8 (26.7)14 (46.7)8 (26.7)30 (100)0.237
Diabetes mellitus10 (83.3)2 (16.7)0 (0.0)12 (100)0.0001*
Congenital heart disease16 (43.2)14 (37.8)7 (18.9)37 (100)0.017*
Malnutrition10 (55.6)3 (16.7)5 (27.8)18 (100)0.021*
Chronic liver disease4 (57.1)2 (28.6)1 (14.3)7 (100)0.031*
Chronic hemolytic anemia4 (21.1)10 (52.6)5 (26.3)19 (100)0.228