Hepatocellular Carcinoma: Tumorigenesis and Prediction Markers

Cornelia Braicu, Claudia Burz, Ioana Berindan-Neagoe, Ovidiu Balacescu, Florin Graur, Victor Cristea, Alexandru Irimie

Abstract


Hepatocellular carcinoma (HCC) is one of the most common malignancies. Although many advances have been made in the clinical study of HCC, the prognosis remains poor. Despite the discoveries in cancer biology in respect with physiological and pathological factors in relation to prognosis, HCC remains still a fatal disease due to late diagnosis. For improving the outcomes of patients with HCC, it is important to identify the factors predisposing to patient death. In recent years, based on cellular and molecular biology techniques, many tumor markers related to invasion, metastasis, recurrence and survival have been explored. However, routine biomarkers for the prediction of HCC evolution and prognosis are available in small number and less specific. These reviews focus on the recent advances in HCC tumorigenesis, revealing those biomarkers with prognosis significance or can be used for early detection.




doi:10.4021/gr2009.07.1304
Publish ahead of print July 23, 2009


Keywords


Hepatocellular carcinoma (HCC); Tumorigenesis; Prediction markers

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Gastroenterology Research, bimonthly, ISSN 1918-2805 (print), 1918-2813 (online), published by Elmer Press Inc.     
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